European journal of medicinal chemistryNeuroprotective AgentsAnimalsMiceIschemic StrokeStructure-Activity Relationship
Discovery of novel pyrrolidine-2,5-dione scaffold PICK1 PDZ inhibitors as anti-ischemic stroke agents.
Yichen Jiang, Qi Liu, Ting Zhu, Ruiguo Liang, Yujiao Qin, Xiya Guo, Jiacheng Wang, Ping Li, Jie Zhou, Han Ju, Mingxin Dong
Published: 202610.1016/j.ejmech.2025.118410
Abstract
Targeting PICK1 presents a promising therapeutic strategy for ischemic stroke. Through multi-level virtual screening, we identified a pyrrolidin-2-one-based hit 3a. Its optimized derivative, 6b, demonstrated potent PICK1 PDZ binding affinity (Ki = 27…
Preview only. Read the full abstract at the source