European journal of medicinal chemistryAlzheimer DiseaseHumansCarbonic Anhydrase InhibitorsAnimalsMice
Exploring dual inhibitors Carbonic Anhydrases and Phosphodiesterase 5 as potential agents for treatment Alzheimer's disease.
Alessia Costa, Gustavo Provensi, Costanza Titi, Manuela Leri, Monica Bucciantini, Marta Ferraroni, Adam B Keeton, Austin M Moore, Gary A Piazza, Ashraf Hassan Abadi, Andrea Angeli, Claudiu T Supuran
Published: 202610.1016/j.ejmech.2025.118404
Abstract
In this study, we report for the first time the design and evaluation of a series of compounds with potential therapeutic relevance for Alzheimer's disease (AD), able to inhibit both human Carbonic Anhydrase (hCA) isoforms most involved in this disea…
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