European journal of medicinal chemistryHumansCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Protein Kinase InhibitorsNeoplasms
Advances in radiolabelled CDK4/6 inhibitors for in vivo imaging of CDK4/6 activity in tumours.
Peiwen Han, Yuhao Jiang, Qing Ruan, Guangxing Yin, Qianna Wang, Junhong Feng, Dajie Ding, Qingna Xiao, Zuojie Li, Junbo Zhang
Published: 202610.1016/j.ejmech.2025.118400
Abstract
Dysregulated cyclin D-CDK4/6-Rb signalling drives uncontrolled proliferation in patients with breast cancer and other malignancies. Although CDK4/6 inhibitors improve patient outcomes, their efficacy is limited by resistance and toxicity, necessitati…
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