European journal of medicinal chemistryHumansAlzheimer DiseaseCholinesterase InhibitorsButyrylcholinesteraseAcetylcholinesterase
Synthesis, biological evaluation, and in silico studies of pyridoxal-amiridine hybrids as multitargeting anti-Alzheimer's disease agents.
G F Makhaeva, M V Grishchenko, E V Rudakova, N V Kovaleva, N P Boltneva, T S Skornyakova, O G Khudina, E V Shchegolkov, E F Zhilina, T Yu Astakhova, P G Pronkin, E N Timokhina, M A Lapshina, E S Dubrovskaya, E V Radchenko
Published: 202610.1016/j.ejmech.2025.118397
Abstract
New conjugates of an anticholinesterase drug, amiridine, linked to vitamin B6 derivatives pyridoximines 3 and pyridoxamines 4 with different lengths of alkylene spacers, were synthesized and assessed as potential multifunctional anti-Alzheimer's dise…
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