European journal of medicinal chemistryHumansTriazolesDrug DesignStructure-Activity RelationshipMolecular Structure
Design, synthesis, and biological properties exhibited by 1,2,3-triazole based Grp94-selective inhibitors.
Hao Xu, Dustin J E Huard, Elijah Dunn, Lucas A Chalfoun, Felix Adulley, Raquel L Lieberman, Brian S J Blagg
Published: 202610.1016/j.ejmech.2025.118394
Abstract
Grp94, the endoplasmic reticulum-resident paralog of Hsp90, is responsible for the folding and maturation of several client proteins including integrins and mutant myocilin. Inhibition of Grp94 with small molecules has been shown to reduce cell migra…
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