European journal of medicinal chemistryGlycyrrhetinic AcidHistone DeacetylasesAnimalsHumansRats
Synthesis and biological evaluations of novel 18β-glycyrrhetinic acid derivatives as histone deacetylase 3 degraders with anti-inflammatory effects.
Huanhuan Qin, Rulong Liu, Yue Shi, Bing Wang, Luhao Guo, Yiting Wang, Guizhou Hao, Guimin Zhang, Dan Liu, Linxiang Zhao, Min Huang
Published: 202610.1016/j.ejmech.2025.118391
Abstract
Histone deacetylase 3 (HDAC3) is implicated in inflammatory signaling, and its degradation represents a promising anti-inflammatory strategy. Based on the 18β-glycyrrhetinic acid analogue COOTO-Me, we designed and synthesized a series of novel deriva…
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