European journal of medicinal chemistryStructure-Activity RelationshipHumansReceptorAdenosine A3Molecular Structure
Structure-activity relationship analysis of 5'-substituted C2-hexynyl-4'-thioadenosine analogs as dual A2A/A3 adenosine receptor agonists with tunable selectivity and anti-inflammatory activity.
Seung Woo Kim, Jahyun Bok, Hongseok Choi, Gibae Kim, Minjae Kim, Yeonseok Chung, Lak Shin Jeong
Published: 202610.1016/j.ejmech.2025.118386
Abstract
Adenosine receptors (ARs), particularly the A2A and A3 receptors are complementary regulators of inflammation, motivating a dual-agonist strategy. We designed, synthesized, and evaluated 2-hexynyl-6-amino 4'-thioadenosine derivatives and established…
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