European journal of medicinal chemistryHumansProtein Kinase InhibitorsPyrimidinesAntineoplastic AgentsTriple Negative Breast Neoplasms
Structural optimization and biological evaluation of 5-fluoro-7H-pyrrolo[2,3- d]pyrimidine derivatives as potent FAK inhibitors for the treatment of triple negative breast cancers (TNBC).
Dongping Zhang, Ziyang Qiu, Hao Lei, Yue Liu, Lijun Zhang, Qian Zhang
Published: 202610.1016/j.ejmech.2025.118370
Abstract
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a crucial role in cancer progression. It is involved in processes such as cell adhesion, motility, proliferation, and survival, and it contributes to tumor drug resistance and m…
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