European journal of medicinal chemistryAnimalsProtein Serine-Threonine KinasesSepsisMiceDrug Design
Design, synthesis, and biological evaluation of novel NIK inhibitors for the treatment of inflammatory bowel disease and sepsis.
Nanxia Zhang, Shige Shen, Jiachen Yuan, Yue Liu, Aoting Ni, Sijie He, Mengyu Yang, Chunyue Xu, Haichun Liu, Qinghua Hu, Jie Feng, Tao Lu, Yadong Chen
Published: 202610.1016/j.ejmech.2025.118368
Abstract
NF-κB-inducing kinase (NIK) plays a pivotal role in activating the non-canonical NF-κB pathway, and its dysregulation has been strongly implicated in autoimmune and inflammatory diseases. In this study, we conducted a structure-based drug design camp…
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