European journal of medicinal chemistryHumansDrug DesignJurkat CellsStructure-Activity RelationshipProtein Serine-Threonine Kinases
Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders.
Zhisheng Zhang, Xuan Zhang, Tizhi Wu, Shengnan Shi, Jiahui Tu, Manqi Zhang, Yan Liang, Mengyang Ma, Sai Zhang, Guangyue Gong, Bing Huang, Ahmed R Ali, Zhixia Qiu, Jinlei Bian, Hongxi Wu
Published: 202610.1016/j.ejmech.2025.118366
Abstract
Hematopoietic progenitor kinase 1 (HPK1), a critical negative regulator of T-cell signaling, has emerged as an attractive yet challenging therapeutic target in immuno-oncology. Inspired by the clinical success of immunomodulatory drugs, we designed a…
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