European journal of medicinal chemistryAnimalsIon ChannelsMiceBrainMolecular Structure
Brain-targeted Jedi1 and Jedi2 derivatives as potent enhancers of Piezo1 ion channel activity.
Landry Anamea, Adéla Králová, Janne Tampio, Anastasia Shakirzyanova, Milka Hänninen, Rashid Giniatullin, Aaro J Jalkanen, Tarja Malm, Kristiina M Huttunen
Published: 202610.1016/j.ejmech.2025.118359
Abstract
Mechanosensitive Piezo1 channel is highly expressed in the eukaryotic central nervous system and involved in many important physiological functions that maintain cell homeostasis. This membrane ion channel is opened by different forms of mechanical a…
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