European journal of medicinal chemistryReceptorsImmunologicHumansMembrane GlycoproteinsSmall Molecule Libraries
TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization.
Hossam Nada, Shaoren Yuan, Farida El Gaamouch, Sungwoo Cho, Katarzyna Kuncewicz, Laura Calvo-Barreiro, Moustafa T Gabr
Published: 202610.1016/j.ejmech.2025.118358
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is a key regulator of microglial function, and its loss-of-function variants are linked to Alzheimer's disease (AD) and neurodegenerative disorders. While TREM2 activation is a promising therap…
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