European journal of medicinal chemistryPyrimidinesRenal InsufficiencyChronicHumansAnimals
Discovery of XRF-1021, a 2,4-disubstituted-5-fluoropyrimidine derivative as a homeodomain-interacting protein kinase 2 inhibitor for the treatment of chronic kidney disease.
Xinlan Hu, Songkai Wang, Songsen Fu, Jianhua Zeng, Yan Wu, Li Gong, Yuanyuan Cao, Yan Zhang, Yuanyuan Han, Hanyi Ouyang, Yiwei Xiong, Xin He, Jiawei Cheng, Sijue Zou, Zhuo Chen
Published: 202610.1016/j.ejmech.2025.118353
Abstract
Homeodomain-interacting protein kinase 2 (HIPK2) has been identified as a promising therapeutic target for chronic kidney disease. In this study, a series of 2,4-disubstituted-5-fluoropyrimidine derivatives were designed and synthesized. Kinase assay…
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