European journal of medicinal chemistryHumansAntineoplastic AgentsTriterpenesAnimalsAmino Acids
Synthesis of β-boswellic acid-amino acid conjugates for targeting KRASG13D mutant colon cancer.
Arem Qayum, Simmi Sharma, Syed Mohmad Shah, Sourav Kumar, Mohamad Sakib Abdullah, Mubashir Javed Mintoo, Anjna Sharma, Utpal Nandi, Naiem Ahmed Wani, Rajkishor Rai, Shashank Kumar Singh, Bhahwal Ali Shah
Published: 202610.1016/j.ejmech.2025.118336
Abstract
The synthesis and cytotoxicity evaluation of a series of β-boswellic acid-amino acid conjugates have been described to enhance anti-cancer efficacy, with a focus on KRASG13D-mutant colorectal cancer (CRC) cells. Among these, compound 8b, which incorp…
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