European journal of medicinal chemistryAnimalsStructure-Activity RelationshipHumansSkinPeptides
Structural insights into frog skin-derived cyclic peptides as selective matriptase inhibitors.
Agata Gitlin-Domagalska, Malihe Hassanzadeh, Aleksandra Helbik-Maciejewska, Matthieu Lepage, Alexandre Joushomme, Antoine Désilets, Dawid Dębowski, Pierre-Luc Boudreault, Richard Leduc, Krzysztof Rolka
Published: 202610.1016/j.ejmech.2025.118331
Abstract
Matriptase is a type II transmembrane serine protease implicated in epithelial integrity and cancer progression, making it a promising therapeutic target. However, the development of highly selective matriptase inhibitors remains a major challenge du…
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