European journal of medicinal chemistryHumansCystic FibrosisSulfate TransportersCystic Fibrosis Transmembrane Conductance RegulatorAnimals
Modulators of anion channels and transporters as alternative therapeutic agents to normalize airway surface liquid in cystic fibrosis.
Alessandra Lipani, Fabiana Lo Mascolo, Stefano Giuffrida, Marilia Barreca, Roberta Bivacqua, Virginia Spanò, Maria Valeria Raimondi, Anna Borrelli, Arianna Venturini, Daniela Guidone, Michele Genovese, Alessandra Montalbano, Luis J V Galietta, Paola Barraja
Published: 202610.1016/j.ejmech.2025.118325
Abstract
Cystic fibrosis (CF) is characterized by impaired chloride and bicarbonate secretion due to mutations in the CFTR gene which codes for a plasma membrane anion channel. Defective anion transport in CF is particularly severe in the respiratory system,…
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