European journal of medicinal chemistryReceptorsCalcitriolLigandsDrug DesignHumans
Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Hansaka Nirupama Thilakarathne Narasinghe Mudiyanselage, Takashi Misawa, Kotaro Ochiai, Yosuke Demizu, Yuya Hanazono, Nobutoshi Ito, Shinya Fujii
Published: 202610.1016/j.ejmech.2025.118320
Abstract
Nonsecosteroidal vitamin D receptor (VDR) ligands are promising drug candidates for multiple diseases, including osteoporosis, psoriasis, and certain cancers. We report here the design, synthesis, biological evaluation and crystallographic analysis o…
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