European journal of medicinal chemistryPleuromutilinsAnti-Bacterial AgentsMicrobial Sensitivity TestsDiterpenesAnimals
Conformationally restricted pleuromutilins via a pyridinyl-amide tether bias peptidyl transferase center engagement enabling broad-spectrum potency against multidrug-resistant bacteria.
Lansheng Zhang, Bingxing Zhang, Lei Tian, Juan Xia, Mengzhou Wang, Hongyu Chang, Tao Hong, Chengyuan Liang, Ming Zhao
Published: 202610.1016/j.ejmech.2025.118316
Abstract
Drug-resistant bacteria are spreading at an alarming rate, yet the global antimicrobial pipeline remains largely dependent on structural modifications of existing antibiotics. In this study, we explore innovative agents targeting multidrug-resistant…
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