European journal of medicinal chemistryHumansCarbonic Anhydrase InhibitorsAntineoplastic AgentsIsatinHydrazones
Click-modifiable isatin hydrazones as COX-2, VEGFR-2, and carbonic anhydrase inhibitors: A multi-target approach to cancer therapy.
Maryam A Z El-Attar, Ola S Afifi, Azza Ismail, Yasmine N Kamel, Hend A Yassin, Hanan Mohamed Nomeir, Hisham A Nematalla, Andrea Angeli, Hala F Labib, Wagdy M Eldehna, Claudiu T Supuran, Ahmed S F Belal, Perihan A Elzahhar, Nayera W Hassan
Published: 202610.1016/j.ejmech.2025.118304
Abstract
In pursuit of novel therapeutic strategies for complex multifactorial diseases such as cancer, a set of isatin hydrazone/1,2,3-triazole hybrids was rationally designed and synthesized to target multiple cancer-related pathways, including COX-2, VEGFR…
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