European journal of medicinal chemistryHumansTranscription FactorsCell ProliferationEthacrynic AcidStructure-Activity Relationship
Discovery of repurposed ethacrynic acid and its derivatives as novel TEAD inhibitors.
Wei Chen, Yuqing Nan, Yiping Zhang, Weidong Han, Yawen Wang, Bing Liu, Yiping Li
Published: 202610.1016/j.ejmech.2025.118299
Abstract
The Hippo pathway, a highly conserved growth-inhibitory signaling cascade, critically regulates fundamental processes including development, tissue homeostasis, and tumorigenesis. Its distal effectors, the homologous oncogenic transcriptional coactiv…
Preview only. Read the full abstract at the source