Synthesis and in silico studies of novel thiophene-celecoxib hybrid with excellent cardiotoxicity and nephrotoxicity safety profiles.

Herein, there was a target to synthesis innovative 1,3,4-trisubstituted pyrazole compounds as thiophene-celecoxib hybrids that had higher anti-inflammatory activity with lower toxicity. Using 1-(4-(methylsulfonyl)phenyl)-3-(thiophen-2-yl)-1H-pyrazole…

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