European journal of medicinal chemistryCarbonic Anhydrase InhibitorsSulfonamidesHumansStructure-Activity RelationshipDrug Discovery
Expanding chemical space of N-acyl sulfonamides for carbonic anhydrase inhibitor discovery.
Oleksii V Gavrylenko, Bohdan V Vashchenko, Vasyl Naumchyk, Oleksii Chuk, Olga Kuchuk, Alla Pogribna, Anzhelika I Konovets, Volodymyr S Brovarets, Sergey A Zozulya, Dmytro S Radchenko, Oleksandr O Grygorenko, Yurii S Moroz
Published: 202610.1016/j.ejmech.2025.118296
Abstract
N-Acyl sulfonamides are widely recognized carboxylic acid isosteres that can fill the gap related to acidic compounds in chemical catalogs and bioactivity studies. This study presents the generation of synthetically tractable N-acyl sulfonamide chemi…
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