European journal of medicinal chemistryHSP90 Heat-Shock ProteinsHumansAntineoplastic AgentsCell ProliferationAnimals
Novel furanone-based anticancer agents: Design, synthesis, Hsp90 inhibition, in vivo antitumor activity and pharmacokinetic studies.
Gina N Tageldin, Hisham A Nematalla, Yomna M Hesham, Ahmed F El-Yazbi, Mahmoud A Agami, Mohamed A Elrewiny, Shams El-Din A Shams El-Din, Elsayed A Badawey, Mai S El-Shoukrofy
Published: 202610.1016/j.ejmech.2025.118278
Abstract
Novel furanone-based hybrids (series A-I) were designed and synthesized as potential anticancer agents and Hsp90 inhibitors using the privileged fragment combination strategy. NCI single-dose full panel assay identified 13b (series I) as the most act…
Preview only. Read the full abstract at the source