European journal of medicinal chemistryMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsThiazolesMicrobial Sensitivity TestsHumans
4-Hydroxy-2,5-dihydrothiazole derivatives as a new class of small-molecule antibiotics for MRSA: AI-integrated design, chemical synthesis and biological evaluation.
Rui Teng, Gao Zhang, Zunsheng Han, Li Li, Xueyao Li, Jing Pang, Song Wu, Jie Xia
Published: 202610.1016/j.ejmech.2025.118266
Abstract
Staphylococcus aureus (S. aureus) is one of the most concerned Gram-positive bacteria due to its resistance to the commonly used antibiotics, methicillin. To address the threat of methicillin-resistant S. aureus (MRSA), new classes of antibiotics are…
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