European journal of medicinal chemistryAnimalsHaemonchusAnthelminticsMiceStructure-Activity Relationship
Fenbendazole-amino acid derivatives as novel anthelmintic candidates: Synthesis, activity against Haemonchus contortus, and in silico profiling.
Maximiliano Colobbio, Ramiro Teixeira, Gerardo Duarte, Mauricio Silvera, Jenny Carolina Saldaña, Magdalena Nieves, Andrea Medeiros, Marcelo Alberto Comini, Laura Domínguez, María Elisa Melian, Beatríz Munguía, Juan Carlos Ramos, Eduardo Manta
Published: 202610.1016/j.ejmech.2025.118247
Abstract
We report the synthesis and biological evaluation of fifteen fenbendazole-amino acid derivatives from a δ-valerolactam-based scaffold. These compounds were designed to enhance anthelmintic efficacy while reducing mammalian cytotoxicity. Their activit…
Preview only. Read the full abstract at the source