European journal of medicinal chemistryBenzofuransHypoglycemic AgentsAntioxidantsDrug DesignAnimals
Harnessing benzofuran scaffolds: A journey through design, synthesis, and biological discovery toward safer anti-diabetic and anti-oxidant candidates.
Mohamed K Elgohary, Mahmoud S Elkotamy, Mariam M Fakhry, Mahmoud Abdelrahman Alkabbani, Abdelhameed Abubakr, Abdallah M Hamdy, Abdel-Aziz S Shatat, Rania S M Ismail, Aya Mohamed Ahmed Ibrahim, Abdulrahman A Almehizia, Ahmed M Naglah, Mayada H Mohamed, Hazem A Ghabbour, Haytham O Tawfik, Wagdy M Eldehna
Published: 202610.1016/j.ejmech.2025.118246
Abstract
A series of benzofuran-based compounds 7a-e, 8a-e, 13a-c, and 17a-e was designed and synthesized through bioisosteric strategies inspired by previously reported studies. These compounds were initially screened for anti-oxidant properties using the DP…
Preview only. Read the full abstract at the source