European journal of medicinal chemistryHumansAntineoplastic AgentsStructure-Activity RelationshipDrug DesignCell Proliferation
Structure-based design and synthesis of 3-substituted-1,2,4-triazolo[1,5-a]pyrimidines as dual vinca/gatorbulin-site ligands for cancer treatment.
Chufeng Zhang, Wei Yan, Hongxiu Chen, Maoru Sun, Fang Wang, Yilin Wang, Shuai Zhang, Li Liu, Qingqing Li, Xiuying Hu, Zhuang Yang, Jianhong Yang, Yong Li
Published: 202610.1016/j.ejmech.2025.118245
Abstract
Our preliminary studies indicate that cevipabulin concurrently binds to both the vinca site and the gatorbulin site, and promotes tubulin degradation. To improve its antiproliferative activity and investigate the structure-activity relationships (SAR…
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