European journal of medicinal chemistryAnti-Bacterial AgentsDrug ResistanceMultipleBacterialMicrobial Sensitivity Tests
Dual-targeting amphiphilic lipopeptides combat multidrug-resistant Gram-positive pathogens by inhibiting type I signal peptidase and disrupting bacterial membrane.
Xiaolin Lu, Xianghan Xu, Xin Kang, Xin Gong, Junli Feng, Mengkang Gao, Hao Yin, Zhi Wang, Xingyu Xia, Jiaqi Zhao, Liping Wang, Dayong Zhang, Jinhu Huang, Menghan Zhang
Published: 202610.1016/j.ejmech.2025.118244
Abstract
Antimicrobial resistance poses a significant threat to global health, particularly with multidrug-resistant (MDR) Gram-positive pathogens evading last-line treatments. We herein designed and synthesized novel amphiphilic lipopeptide derivatives to ex…
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