European journal of medicinal chemistryMyeloid Cell Leukemia Sequence 1 ProteinHumansBenzimidazolesStructure-Activity RelationshipAntineoplastic Agents
Discovery of benzimidazole-based Mcl-1 inhibitors via AlphaShape-enabled virtual screening.
Yiming Nie, Jintong Du, Xin Yan, Haihan Liu, Jiaqi Liu, Hu Ge, Hao Fang, Xuben Hou
Published: 202610.1016/j.ejmech.2025.118229
Abstract
As an essential regulator of tumor cell survival mechanisms, myeloid cell leukemia 1 (Mcl-1) represents a promising anti-cancer target. This study describes the identification of novel benzimidazole scaffolds targeting Mcl-1 through AlphaShape, a dee…
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