European journal of medicinal chemistryAntidepressive AgentsAnimalsDrug DesignHumansMice
Design, synthesis, and biological profiling of novel aryl-spirocyclic diamine derivatives with potential antidepressant-like properties.
Jiefang Zheng, Yaxin Tian, Jiaxin Cheng, Zhengtao Hu, Junchi Zhang, Feipu Yang, Pengcheng Li, Zhijuan Jiang, Xudong Gong, Qiongqiong Hou, Guan Wang, Vivien Shen, Tianwen Hu, Zhijian Xu, Guanghui Tian
Published: 202610.1016/j.ejmech.2025.118198
Abstract
To meet the clinical need for therapeutic efficacy against cognitive impairment and pain comorbidities in depression, a rational drug design approach was used in the current study to synthesize a series of spirocyclic diamine derivatives. Among them,…
Preview only. Read the full abstract at the source