European journal of medicinal chemistryHumansProtein Kinase InhibitorsStructure-Activity RelationshipAntineoplastic AgentsReceptor
Research progress of TRK inhibitors and their structure-activity relationship.
Yao-Yao Ye, Ruo-Xuan Xu, Wen Zhang, Guo-Wu Rao, Quan Zheng
Published: 202610.1016/j.ejmech.2025.118183
Abstract
Neurotrophic tyrosine receptor kinase (NTRK) is a member of the transmembrane receptor tyrosine kinase family. The TRK protein preserves the survival and regular operation of nerve cells and is intimately linked to cell division, proliferation, metab…
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