European journal of cancer (Oxford, England : 1990)HumansFemaleMaleMiddle AgedAdult
Cancer risks for MSH6 pathogenic variant carriers.
Anne-Sophie van der Werf-'t Lam, James G Dowty, Morrison Italia, Astrid C Bakker, Fernande Koops, Fonnet Bleeker, Encarna Gomez-Garcia, Liselot P van Hest, Hans J P Gille, Claire C Cornips, Mirjam M de Jong, Tom G W Letteboer, Floor A M Duijkers, Anja Wagner, Ellis L Eikenboom
Published: 202510.1016/j.ejca.2025.116098
Abstract
INTRODUCTION: Lynch syndrome (LS) is a hereditary cancer syndrome caused by pathogenic variants (PVs) in DNA mismatch repair genes, including MSH6. Although MSH6-associated LS (MSH6-LS) is known to increase the risk of several cancers, precise risk e…
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