Manganese disrupts lipid droplet autophagy and drives A1 astrocyte activation via the LAMP2-PLIN2 axis through mTOR-p70S6K1 signaling pathway.

Manganese (Mn), the fifth most abundant metal in Earth's crust, is extensively mined for industrial, energy, and agricultural applications, resulting in excess human exposure. Mn accumulates in the central nervous system (CNS) and triggers neurotoxic…

Preview only. Read the full abstract at the source