Ecotoxicology and environmental safetyAnimalsSirtuin 1RotenoneNF-E2-Related Factor 2Cognitive Dysfunction
The activation of SIRT1-Nrf2 axis exerts beneficial effects against rotenone-induced cognitive deficits in mice through inhibition of neuroinflammation and ferroptosis.
Yu Ma, Jiahang Zhang, Qixuan Zhou, Peiyan Tang, Xin Wang, Haotianyu Zhu, Zihan Huang, Hong Su, Xingyue Zhai, Qingshan Wang
Published: 202610.1016/j.ecoenv.2026.119697
Abstract
Rotenone, a widely used agricultural pesticide has been linked to an increased risk of Parkinson's disease (PD) following chronic exposure. Our previous study found that rotenone not only caused motor deficits in mice, but was also able to cause cogn…
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