Ecotoxicology and environmental safetyCarcinomaHepatocellularLiver NeoplasmsHumansEndocrine Disruptors
Integrated multi-Omics and network toxicology elucidate the multi-target mechanisms of environmental hormones in driving hepatocellular carcinoma.
Rong Huang, Jinyue Ma, Jiaxin Yao, Jiyu Pang, Min Zhang, Lu Wen, Liang Wang, Yanan Deng, Xiu He, Chunyan Zhao, Bo Mu
Published: 202610.1016/j.ecoenv.2025.119519
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is a major malignancy with rising global incidence and mortality. Clinical treatment is limited by molecular heterogeneity and drug resistance. In recent years, endocrine-disrupting chemicals (EDCs) have att…
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