Ecotoxicology and environmental safetyAnimalsCalcium OxalateKidney CalculiApoptosisMice
Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization.
Heng Xiang, Yijun Yang, Liang Chen, Ziqi He, Qixuan Zhou, Caitao Dong, Qinhong Jiang, Qingfeng Chen, Xiaozhe Su, Sixing Yang
Published: 202510.1016/j.ecoenv.2025.119481
Abstract
We systematically evaluated how cadmium (Cd) exposure synergizes with calcium oxalate (CaOx) to promote kidney stone formation and renal injury, focusing on the central role of thioredoxin-interacting protein (TXNIP). Clinical kidney stones, in vitro…
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