Ecotoxicology and environmental safetyFemaleDiethylhexyl PhthalateAdenosine TriphosphateAnimalsPregnancy
Di-(2-ethylhexyl)-phthalate exposure impairs placental P-glycoprotein efflux function by reducing protein expression and ATP levels.
Changing Tang, Kunpeng Ren, Miao Hou, Zhiheng Liu, Jiaying Zhang, Guanghui Qian, Mengying Zuo, Ling Sun, Haitao Lv
Published: 202510.1016/j.ecoenv.2025.119478
Abstract
Di(2-ethylhexyl)phthalate (DEHP), a widespread environmental plasticizer, is linked to adverse pregnancy outcomes, including congenital heart defects. Placenta forms a critical barrier, with P-glycoprotein (P-gp), an ATP-dependent efflux transporter,…
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