Ecotoxicology and environmental safetyPPAR gammaHigh-Throughput Screening AssaysHumansPulmonary FibrosisLuciferases
PPARγ-responsive luciferase reporter system for high-throughput screening of chemical toxins with potential pulmonary fibrosis effects.
Xueyang Lin, Yi Yang, Yangyang Sun, Weijie Yang, Shengran Wang, Weidong Li, Zhenghao Bao, Ziqi Cui, Yufeng Yang, Simin Lang, Chen Yang, Weiqiang Sun, Xin Sui, Wenya Feng, Xianli Du
Published: 202510.1016/j.ecoenv.2025.119433
Abstract
BACKGROUND: Pulmonary fibrosis (PF) is a progressive and fatal lung disorder, and emerging evidence suggests that dysregulation of peroxisome proliferator-activated receptor gamma (PPARγ) plays a critical role in its pathogenesis. However, high-throu…
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