Ecotoxicology and environmental safetyAnimalsMaleFemaleAquaporin 1Amyloid beta-Peptides
Maternal cadmium exposure promotes amyloid-beta pathology by interrupting the interaction of AQP1 and HCN1 in male offspring.
Wanwen Mai, Dong Peng, Luyi Wu, Ning Gao, Xiang Zhang, Runze Zhang, Rongyao Chen, Xinyi Zhong, Hongxia Chen, Qiuling Xie, Qihao Zhang
Published: 202510.1016/j.ecoenv.2025.119238
Abstract
Maternal cadmium (Cd) exposure induces Alzheimer's disease (AD)-like cognitive decline in male offspring, yet the precise mechanisms remain poorly understood. Proteomic analysis identified AQP1 as a key protein in the hippocampus of male offspring ra…
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