Ecotoxicology and environmental safetyParabensHydrocortisone11-beta-Hydroxysteroid Dehydrogenase Type 2HumansAnimals
Inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 by parabens: Mechanistic insights into cortisol metabolism disruption and structure-activity relationship and in silico docking.
Xishi Chen, Jingyi Zheng, Chentao Ding, Chunnan Hu, Yunbing Tang, Yingfen Ying, Renshan Ge, Huitao Li
Published: 202510.1016/j.ecoenv.2025.119174
Abstract
Parabens are widely used as antimicrobial preservatives in cosmetics, personal care products, and pharmaceuticals. However, their endocrine-disrupting potential, particularly their impact on 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), remains…
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