Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
Single-cell transcriptome analysis of patient-derived organoids captures inter- and intratumor heterogeneity and uncovers targetable pathways in high grade serous ovarian cancer.
Marco Pieraccioli, Alessandra Ciucci, Christian Corti, Roberta Mastrantonio, Eleonora Kristina Scarpone, Eleonora Cesari, Alessia Piermattei, Angelo Minucci, Andrea Urbani, Floriana Camarda, Anna Fagotti, Luca Tamagnone, Giovanni Scambia, Camilla Nero, Claudio Sette
Published: 202610.1016/j.drup.2026.101354
Abstract
AIM: High grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer. HGSOC is characterized by high inter- and intra-tumoral heterogeneity, which contributes to chemotherapy resistance. Patient-derived organoids (PDOs) are…
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