Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapyHumansMicroRNAsDrug ResistanceNeoplasmTriple Negative Breast Neoplasms
Y10 phosphorylation of LDHA promotes the release of extracellular vesicle-derived circSEPT9 to enhance the chemoresistance of triple negative breast cancer cells via modulation of the miR-515-5p/KIAA1429 axis.
Yueping Wang, Ziyun Zhang, Juan Gu, Ming Zhou, Jiankang Huang, Daoping Zhou, Xuedong Wang
Published: 202610.1016/j.drup.2025.101324
Abstract
OBJECTIVE: Extracellular vesicle (EV)-derived RNAs play crucial roles in cancer biology and therapeutic resistance. This study investigated how EV-derived circSEPT9 mediates doxorubicin (DOX) resistance in triple negative breast cancer (TNBC). METHOD…
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