Drug discovery today
Organoids in drug development: from predictive models to regulatory integration.
Xuyang Song, Xinrong Chen, Qing Chen, Hao Wang, Tao Zhang, Michael Z Liao, Chunhong Liu, Hongtao Yu, Yanning Hao, Guodong Gu, Zehua Cheng, Zhiyao Zhu, Yongbin Zhang, Suchitra K Hourigan
Published: 202610.1016/j.drudis.2026.104608
Abstract
Organoids offer superior physiological relevance over traditional 2D and animal models. By recapitulating human tissue architecture, they enable predictive assessments of drug efficacy, toxicity, and pharmacokinetics (DMPK). Integrating artificial in…
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