DNA repairTopoisomerase I InhibitorsDNA ReplicationHumansDNA TopoisomerasesType I
Stepwise DNA damage and repair mechanisms at replication forks in response to topoisomerase I inhibition.
Sofie Østergård Bæk, Kristina Keuper, Giacomo Milletti, Alba Adelantado-Rubio, Michael Lisby, Jiri Bartek, Christoffel Dinant, Apolinar Maya-Mendoza
Published: 202610.1016/j.dnarep.2025.103914
Abstract
Camptothecin (CPT) and its derivative irinotecan inhibit DNA topoisomerase I (TOP1), inducing replication stress by stabilizing the TOP1 cleavage complex. This prevents DNA re-ligation, resulting in single-stranded breaks that, if unresolved, can cau…
Preview only. Read the full abstract at the source