Drug metabolism and pharmacokinetics
Evaluation of OATP1B inhibitory potential using an endogenous biomarker coproporphyrin-I in new drug applications: Case reports submitted by 2024.
Ryosuke Watari
Published: 202510.1016/j.dmpk.2025.101513
Abstract
Coproporphyrin-I (CP-I), an endogenous biomarker for organic anion transporting polypeptide (OATP) 1B, is a critical tool for evaluating the inhibitory potential of OATP1B in humans. The final International Council for Harmonisation of Technical Requ…
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