Drug metabolism and pharmacokineticsHumansSimvastatinCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemHydroxymethylglutaryl-CoA Reductase Inhibitors
Metabolism of simvastatin by Streptomyces griseolus CYP105A1 and its variants for the production of human simvastatin metabolites.
Sachiyo Yoneda, Kaori Yasuda, Bunzo Mikami, Teisuke Takita, Kiyoshi Yasukawa, Masahiro Hamada, Hiromasa Imaishi, Toshiyuki Sakaki, Shinichi Ikushiro
Published: 202510.1016/j.dmpk.2025.101506
Abstract
Streptomyces griseolus CYP105A1 showed hydroxylation activity at 25- and 1α-positions of vitamin D3 to produce an active form of vitamin D3. We have succeeded in dramatically increasing its activity by site-directed mutagenesis. We also found that CY…
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