Drug metabolism and pharmacokineticsGlutathioneCyanidesCarbon RadioisotopesHumansPharmaceutical Preparations
A novel quantitative assessment of formed reactive metabolites by double trapping with [3H]glutathione and [14C]cyanide.
Tomoyuki Kawachi, Tatsuki Fukami, Miki Nakajima
Published: 202510.1016/j.dmpk.2025.101504
Abstract
Drug-induced liver injury often arises from reactive metabolites (RMs) produced in the liver, making it crucial to assess RM formation rates from drug candidates. Conventional assays using glutathione (GSH) effectively trap soft electrophilic RMs but…
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