Drug metabolism and disposition: the biological fate of chemicals
Insights into the human pharmacokinetics and metabolism of branaplam, a splicing modulator of a survival motor neuron-2 and huntingtin pre-mRNAs, in infants and adults.
F Lozac'h, A Demailly, M Raccuglia, A D James, M Walles, B Borowsky, T Faller
Published: 202510.1016/j.dmd.2025.100219
Abstract
This study examined the absorption, distribution, metabolism, and excretion of branaplam in healthy adult male volunteers and, additionally, compared the adult metabolite profiles obtained in plasma and urine to those obtained in infants with type 1…
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