Drug metabolism and disposition: the biological fate of chemicals
Untargeted metabolomic profiling of fasting plasma uncovers early biochemical responses following a therapeutic dose of paracetamol.
Faris Almutairi, Mohammed A Assiri, Abdulrahman Alwhaibi, Fawaz Alasmari, Shuruq Alsuhaymi, Mariusz Jaremko, Abdul-Hamid Emwas, Enas Alsawaq, Omar A Almohammed, Sary Alsanea
Published: 202510.1016/j.dmd.2025.100216
Abstract
Paracetamol is one of the most frequently used medications worldwide because of its analgesic and antipyretic properties. Despite its widespread use, its effects on metabolic changes in human plasma are unclear. This study aimed to assess the impact…
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