Drug metabolism and disposition: the biological fate of chemicals
Three-dimensional-cultured renal tubular model reveals FXR-HNF4α-OAT1/3 axis as a target for preventing nucleotide analog-induced kidney injury.
Itsuki Yokoseki, Masataka Nakano, Etsushi Takahashi, Kaoru Morimura, Yukiko Nishioka, Ayano Araki, Yoichi Jimbo, Naoki Ishiguro, Hiroshi Arawaka, Ikumi Tamai, Tatsuki Fukami, Miki Nakajima
Published: 202510.1016/j.dmd.2025.100214
Abstract
Drug-induced kidney injury, often resulting from the intracellular accumulation of drugs in renal proximal tubule cells via uptake transporters such as organic anion transporters 1 and 3 (OAT1/3), remains a major obstacle in drug development. Convent…
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